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Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score

OBJECTIVES: To assess factors associated with renal dysfunction (RD) in hepatitis C virus (HCV) cirrhosis, correlate renal parameters with Child-Pugh score (CPS) and find a cut-off value of CPS to determine RD. MATERIALS AND METHODS: It was a cross-sectional study that included 70 cases of liver cir...

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Autores principales: Bhatti, Hamza Waqar, Tahir, Umama, Chaudhary, Noman Ahmed, Bhatti, Sania, Hafeez, Muhammad, Rizvi, Zuhair Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577365/
https://www.ncbi.nlm.nih.gov/pubmed/31275583
http://dx.doi.org/10.1136/bmjgast-2019-000286
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author Bhatti, Hamza Waqar
Tahir, Umama
Chaudhary, Noman Ahmed
Bhatti, Sania
Hafeez, Muhammad
Rizvi, Zuhair Ali
author_facet Bhatti, Hamza Waqar
Tahir, Umama
Chaudhary, Noman Ahmed
Bhatti, Sania
Hafeez, Muhammad
Rizvi, Zuhair Ali
author_sort Bhatti, Hamza Waqar
collection PubMed
description OBJECTIVES: To assess factors associated with renal dysfunction (RD) in hepatitis C virus (HCV) cirrhosis, correlate renal parameters with Child-Pugh score (CPS) and find a cut-off value of CPS to determine RD. MATERIALS AND METHODS: It was a cross-sectional study that included 70 cases of liver cirrhosis secondary to HCV from a period of 6 months at Combined Military Hospital, Multan. Diagnosis of HCV was confirmed by serological assay and liver cirrhosis by ultrasonography. CPS was determined and lab reports were taken. Patients were divided into two groups as not having RD (serum creatinine≤1.5 mg/dL) and having RD (serum creatinine≥1.5 mg/dL). Estimated glomerular filtration rate (eGFR) was calculated by chronic kidney disease epidemiology collaboration (CKD-EPI) formula. Data were analyzed using SPSS V.23.0. χ(2), Kruskal-Wallis test and Pearson coefficient of correlation were applied. ROC curve was drawn to evaluate cut-off value of CPS for the presence of RD. Level of significance was set at p<0.05. RESULTS: Patients with CP grade B or C develop RD as compared to patients with CP grade A (p=0.000). Mean age, urea, creatinine and eGFR varies significantly among patients who develop RD and patients who do not (p=0.02, p=0.000, p=0.000 and p=0.000, respectively). eGFR negatively correlates with CPS (r=−0.359, p=0.002). Creatinine, urea and ALBI score positively correlates with CPS (r=+0.417, p=0.000; r=+0.757, p=0.000; r=+0.362, p=0.002, respectively). CONCLUSION: Ascites and encephalopathy are associated with RD in HCV cirrhosis.
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spelling pubmed-65773652019-07-02 Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score Bhatti, Hamza Waqar Tahir, Umama Chaudhary, Noman Ahmed Bhatti, Sania Hafeez, Muhammad Rizvi, Zuhair Ali BMJ Open Gastroenterol Hepatology OBJECTIVES: To assess factors associated with renal dysfunction (RD) in hepatitis C virus (HCV) cirrhosis, correlate renal parameters with Child-Pugh score (CPS) and find a cut-off value of CPS to determine RD. MATERIALS AND METHODS: It was a cross-sectional study that included 70 cases of liver cirrhosis secondary to HCV from a period of 6 months at Combined Military Hospital, Multan. Diagnosis of HCV was confirmed by serological assay and liver cirrhosis by ultrasonography. CPS was determined and lab reports were taken. Patients were divided into two groups as not having RD (serum creatinine≤1.5 mg/dL) and having RD (serum creatinine≥1.5 mg/dL). Estimated glomerular filtration rate (eGFR) was calculated by chronic kidney disease epidemiology collaboration (CKD-EPI) formula. Data were analyzed using SPSS V.23.0. χ(2), Kruskal-Wallis test and Pearson coefficient of correlation were applied. ROC curve was drawn to evaluate cut-off value of CPS for the presence of RD. Level of significance was set at p<0.05. RESULTS: Patients with CP grade B or C develop RD as compared to patients with CP grade A (p=0.000). Mean age, urea, creatinine and eGFR varies significantly among patients who develop RD and patients who do not (p=0.02, p=0.000, p=0.000 and p=0.000, respectively). eGFR negatively correlates with CPS (r=−0.359, p=0.002). Creatinine, urea and ALBI score positively correlates with CPS (r=+0.417, p=0.000; r=+0.757, p=0.000; r=+0.362, p=0.002, respectively). CONCLUSION: Ascites and encephalopathy are associated with RD in HCV cirrhosis. BMJ Publishing Group 2019-05-19 /pmc/articles/PMC6577365/ /pubmed/31275583 http://dx.doi.org/10.1136/bmjgast-2019-000286 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Hepatology
Bhatti, Hamza Waqar
Tahir, Umama
Chaudhary, Noman Ahmed
Bhatti, Sania
Hafeez, Muhammad
Rizvi, Zuhair Ali
Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title_full Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title_fullStr Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title_full_unstemmed Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title_short Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with Child-Pugh score
title_sort factors associated with renal dysfunction in hepatitis c-related cirrhosis and its correlation with child-pugh score
topic Hepatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577365/
https://www.ncbi.nlm.nih.gov/pubmed/31275583
http://dx.doi.org/10.1136/bmjgast-2019-000286
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