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Extracellular matrix components modulate different stages in β(2)-microglobulin amyloid formation

Amyloid deposition of WT human β(2)-microglobulin (WT-hβ(2)m) in the joints of long-term hemodialysis patients is the hallmark of dialysis-related amyloidosis. In vitro, WT-hβ(2)m does not form amyloid fibrils at physiological pH and temperature unless co-solvents or other reagents are added. Theref...

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Detalles Bibliográficos
Autores principales:	Benseny-Cases, Núria, Karamanos, Theodoros K., Hoop, Cody L., Baum, Jean, Radford, Sheena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579475/ https://www.ncbi.nlm.nih.gov/pubmed/30996004 http://dx.doi.org/10.1074/jbc.RA119.008300

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