Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

The fusion peptide (FP) of HIV-1 envelope glycoprotein (Env) is essential for mediating viral entry. Detection of broadly neutralizing antibodies (bnAbs) that interact with the FP has revealed it as a site of vulnerability. We delineate X-ray and cryo-electron microscopy (cryo-EM) structures of bnAb...

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Detalles Bibliográficos
Autores principales: Yuan, Meng, Cottrell, Christopher A., Ozorowski, Gabriel, van Gils, Marit J., Kumar, Sonu, Wu, Nicholas C., Sarkar, Anita, Torres, Jonathan L., de Val, Natalia, Copps, Jeffrey, Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579543/
https://www.ncbi.nlm.nih.gov/pubmed/31194940
http://dx.doi.org/10.1016/j.chom.2019.04.011

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