Cas9(+) conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond

Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells. Here we report a facile system for genome editing in non-transformed macrophages...

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Detalles Bibliográficos
Autores principales: Roberts, Allison W, Popov, Lauren M, Mitchell, Gabriel, Ching, Krystal L, Licht, Daniel J, Golovkine, Guillaume, Barton, Gregory M, Cox, Jeffery S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579556/
https://www.ncbi.nlm.nih.gov/pubmed/31204998
http://dx.doi.org/10.7554/eLife.45957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579556/
https://www.ncbi.nlm.nih.gov/pubmed/31204998
http://dx.doi.org/10.7554/eLife.45957

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