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Cas9(+) conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond
Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells. Here we report a facile system for genome editing in non-transformed macrophages...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579556/ https://www.ncbi.nlm.nih.gov/pubmed/31204998 http://dx.doi.org/10.7554/eLife.45957 |