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Toward a Model for Activation of Orai Channel
Store-operated calcium release-activated calcium (CRAC) channels mediate a variety of cellular signaling functions. The CRAC channel pore-forming protein, Orai1, is a hexamer arranged with 3-fold symmetry. Despite its importance in moving Ca(2+) ions into cells, a detailed mechanistic understanding...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579751/ https://www.ncbi.nlm.nih.gov/pubmed/31207498 http://dx.doi.org/10.1016/j.isci.2019.05.041 |