Cargando…

Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice

Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ueno, Hiroshi, Shimada, Atsumi, Suemitsu, Shunsuke, Murakami, Shinji, Kitamura, Naoya, Wani, Kenta, Matsumoto, Yosuke, Okamoto, Motoi, Fujiwara, Yuko, Ishihara, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579855/
https://www.ncbi.nlm.nih.gov/pubmed/31431930
http://dx.doi.org/10.1016/j.heliyon.2019.e01945
_version_ 1783427917766721536
author Ueno, Hiroshi
Shimada, Atsumi
Suemitsu, Shunsuke
Murakami, Shinji
Kitamura, Naoya
Wani, Kenta
Matsumoto, Yosuke
Okamoto, Motoi
Fujiwara, Yuko
Ishihara, Takeshi
author_facet Ueno, Hiroshi
Shimada, Atsumi
Suemitsu, Shunsuke
Murakami, Shinji
Kitamura, Naoya
Wani, Kenta
Matsumoto, Yosuke
Okamoto, Motoi
Fujiwara, Yuko
Ishihara, Takeshi
author_sort Ueno, Hiroshi
collection PubMed
description Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
format Online
Article
Text
id pubmed-6579855
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-65798552019-08-20 Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice Ueno, Hiroshi Shimada, Atsumi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Matsumoto, Yosuke Okamoto, Motoi Fujiwara, Yuko Ishihara, Takeshi Heliyon Article Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention. Elsevier 2019-06-14 /pmc/articles/PMC6579855/ /pubmed/31431930 http://dx.doi.org/10.1016/j.heliyon.2019.e01945 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ueno, Hiroshi
Shimada, Atsumi
Suemitsu, Shunsuke
Murakami, Shinji
Kitamura, Naoya
Wani, Kenta
Matsumoto, Yosuke
Okamoto, Motoi
Fujiwara, Yuko
Ishihara, Takeshi
Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title_full Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title_fullStr Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title_full_unstemmed Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title_short Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
title_sort anti-stress effects of the hydroalcoholic extract of rosa gallica officinalis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579855/
https://www.ncbi.nlm.nih.gov/pubmed/31431930
http://dx.doi.org/10.1016/j.heliyon.2019.e01945
work_keys_str_mv AT uenohiroshi antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT shimadaatsumi antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT suemitsushunsuke antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT murakamishinji antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT kitamuranaoya antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT wanikenta antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT matsumotoyosuke antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT okamotomotoi antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT fujiwarayuko antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice
AT ishiharatakeshi antistresseffectsofthehydroalcoholicextractofrosagallicaofficinalisinmice