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Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579855/ https://www.ncbi.nlm.nih.gov/pubmed/31431930 http://dx.doi.org/10.1016/j.heliyon.2019.e01945 |
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author | Ueno, Hiroshi Shimada, Atsumi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Matsumoto, Yosuke Okamoto, Motoi Fujiwara, Yuko Ishihara, Takeshi |
author_facet | Ueno, Hiroshi Shimada, Atsumi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Matsumoto, Yosuke Okamoto, Motoi Fujiwara, Yuko Ishihara, Takeshi |
author_sort | Ueno, Hiroshi |
collection | PubMed |
description | Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention. |
format | Online Article Text |
id | pubmed-6579855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-65798552019-08-20 Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice Ueno, Hiroshi Shimada, Atsumi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Matsumoto, Yosuke Okamoto, Motoi Fujiwara, Yuko Ishihara, Takeshi Heliyon Article Rosa gallica, a plant of the Rosa genus, has been used widely since the 13(th) century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention. Elsevier 2019-06-14 /pmc/articles/PMC6579855/ /pubmed/31431930 http://dx.doi.org/10.1016/j.heliyon.2019.e01945 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Ueno, Hiroshi Shimada, Atsumi Suemitsu, Shunsuke Murakami, Shinji Kitamura, Naoya Wani, Kenta Matsumoto, Yosuke Okamoto, Motoi Fujiwara, Yuko Ishihara, Takeshi Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title | Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title_full | Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title_fullStr | Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title_full_unstemmed | Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title_short | Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice |
title_sort | anti-stress effects of the hydroalcoholic extract of rosa gallica officinalis in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579855/ https://www.ncbi.nlm.nih.gov/pubmed/31431930 http://dx.doi.org/10.1016/j.heliyon.2019.e01945 |
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