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Recent advances in the treatment of C. difficile using biotherapeutic agents
Clostridium difficile (C. difficile) is rapidly becoming one of the most prevalent health care–associated bacterial infections in the developed world. The emergence of new, more virulent strains has led to greater morbidity and resistance to standard therapies. The bacterium is readily transmitted b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579870/ https://www.ncbi.nlm.nih.gov/pubmed/31354309 http://dx.doi.org/10.2147/IDR.S207572 |
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author | Giau, Vo Van Lee, Hyon An, Seong Soo A Hulme, John |
author_facet | Giau, Vo Van Lee, Hyon An, Seong Soo A Hulme, John |
author_sort | Giau, Vo Van |
collection | PubMed |
description | Clostridium difficile (C. difficile) is rapidly becoming one of the most prevalent health care–associated bacterial infections in the developed world. The emergence of new, more virulent strains has led to greater morbidity and resistance to standard therapies. The bacterium is readily transmitted between people where it can asymptomatically colonize the gut environment, and clinical manifestations ranging from frequent watery diarrhea to toxic megacolon can arise depending on the age of the individual or their state of gut dysbiosis. Several inexpensive approaches are shown to be effective against virulent C. difficile in research settings such as probiotics, fecal microbiota transfer and immunotherapies. This review aims to highlight the current advantages and limitations of the aforementioned approaches with an emphasis on recent studies. |
format | Online Article Text |
id | pubmed-6579870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-65798702019-07-26 Recent advances in the treatment of C. difficile using biotherapeutic agents Giau, Vo Van Lee, Hyon An, Seong Soo A Hulme, John Infect Drug Resist Review Clostridium difficile (C. difficile) is rapidly becoming one of the most prevalent health care–associated bacterial infections in the developed world. The emergence of new, more virulent strains has led to greater morbidity and resistance to standard therapies. The bacterium is readily transmitted between people where it can asymptomatically colonize the gut environment, and clinical manifestations ranging from frequent watery diarrhea to toxic megacolon can arise depending on the age of the individual or their state of gut dysbiosis. Several inexpensive approaches are shown to be effective against virulent C. difficile in research settings such as probiotics, fecal microbiota transfer and immunotherapies. This review aims to highlight the current advantages and limitations of the aforementioned approaches with an emphasis on recent studies. Dove 2019-06-10 /pmc/articles/PMC6579870/ /pubmed/31354309 http://dx.doi.org/10.2147/IDR.S207572 Text en © 2019 Giau et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Giau, Vo Van Lee, Hyon An, Seong Soo A Hulme, John Recent advances in the treatment of C. difficile using biotherapeutic agents |
title | Recent advances in the treatment of C. difficile using biotherapeutic agents |
title_full | Recent advances in the treatment of C. difficile using biotherapeutic agents |
title_fullStr | Recent advances in the treatment of C. difficile using biotherapeutic agents |
title_full_unstemmed | Recent advances in the treatment of C. difficile using biotherapeutic agents |
title_short | Recent advances in the treatment of C. difficile using biotherapeutic agents |
title_sort | recent advances in the treatment of c. difficile using biotherapeutic agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579870/ https://www.ncbi.nlm.nih.gov/pubmed/31354309 http://dx.doi.org/10.2147/IDR.S207572 |
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