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Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2(+/−) Mice

In tuberous sclerosis (TSC)–associated tumors, mutations in the TSC genes lead to aberrant activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. mTORC1 signaling impacts many biological processes including the epithelial-mesenchymal transition (EMT), which is sugges...

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Detalles Bibliográficos
Autores principales:	Jones, Ashley T., Yang, Jian, Narov, Kalin, Henske, Elizabeth P, Sampson, Julian R., Shen, Ming Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2019
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580094/ https://www.ncbi.nlm.nih.gov/pubmed/31207499 http://dx.doi.org/10.1016/j.neo.2019.05.003

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