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Data from quantitative serum proteomic analysis after laparoscopic gastric plication
Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580113/ https://www.ncbi.nlm.nih.gov/pubmed/31431912 http://dx.doi.org/10.1016/j.dib.2019.104077 |
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author | Savedoroudi, Parisa Bennike, Tue Bjerg Kastaniegaard, Kenneth Talebpour, Mohammad Ghassempour, Alireza Stensballe, Allan |
author_facet | Savedoroudi, Parisa Bennike, Tue Bjerg Kastaniegaard, Kenneth Talebpour, Mohammad Ghassempour, Alireza Stensballe, Allan |
author_sort | Savedoroudi, Parisa |
collection | PubMed |
description | Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a new bariatric surgery. Pre-surgery serum samples of obese individuals were compared with the serum of the same subjects 1–2 months post-surgery (T1) and 4–5 months post-surgery (T2). The data provide a list of 224 quantifiable proteins with at least two unique peptides that were quantifiable in at least 70% of samples. Gene ontology biological processes and molecular functions of differentially regulated proteins between pre- and post-surgery samples were investigated using WebGestalt online tool. In addition, molecular networks of differentially abundant proteins were determined through Ingenuity Pathway Analysis (IPA) software. This report is related to the research article entitled “Serum proteome changes and accelerated reduction of fat mass after Laparoscopic Gastric Plication in morbidly obese patients” (Savedoroudi et al. [1]). Proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository through the identifier PXD010528. |
format | Online Article Text |
id | pubmed-6580113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-65801132019-08-20 Data from quantitative serum proteomic analysis after laparoscopic gastric plication Savedoroudi, Parisa Bennike, Tue Bjerg Kastaniegaard, Kenneth Talebpour, Mohammad Ghassempour, Alireza Stensballe, Allan Data Brief Biochemistry, Genetics and Molecular Biology Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a new bariatric surgery. Pre-surgery serum samples of obese individuals were compared with the serum of the same subjects 1–2 months post-surgery (T1) and 4–5 months post-surgery (T2). The data provide a list of 224 quantifiable proteins with at least two unique peptides that were quantifiable in at least 70% of samples. Gene ontology biological processes and molecular functions of differentially regulated proteins between pre- and post-surgery samples were investigated using WebGestalt online tool. In addition, molecular networks of differentially abundant proteins were determined through Ingenuity Pathway Analysis (IPA) software. This report is related to the research article entitled “Serum proteome changes and accelerated reduction of fat mass after Laparoscopic Gastric Plication in morbidly obese patients” (Savedoroudi et al. [1]). Proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository through the identifier PXD010528. Elsevier 2019-05-30 /pmc/articles/PMC6580113/ /pubmed/31431912 http://dx.doi.org/10.1016/j.dib.2019.104077 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Biochemistry, Genetics and Molecular Biology Savedoroudi, Parisa Bennike, Tue Bjerg Kastaniegaard, Kenneth Talebpour, Mohammad Ghassempour, Alireza Stensballe, Allan Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title | Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title_full | Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title_fullStr | Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title_full_unstemmed | Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title_short | Data from quantitative serum proteomic analysis after laparoscopic gastric plication |
title_sort | data from quantitative serum proteomic analysis after laparoscopic gastric plication |
topic | Biochemistry, Genetics and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580113/ https://www.ncbi.nlm.nih.gov/pubmed/31431912 http://dx.doi.org/10.1016/j.dib.2019.104077 |
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