Cargando…

Prompt apoptotic response to high glucose in SGLT-expressing renal cells

It is generally believed that cells that are unable to downregulate glucose transport are particularly vulnerable to hyperglycemia. Yet, little is known about the relation between expression of glucose transporters and acute toxic effects of high glucose exposure. In the present ex vivo study of rat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nilsson, Linnéa M., Zhang, Liang, Bondar, Alexander, Svensson, Daniel, Wernerson, Annika, Brismar, Hjalmar, Scott, Lena, Aperia, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580252/ https://www.ncbi.nlm.nih.gov/pubmed/30864838 http://dx.doi.org/10.1152/ajprenal.00615.2018

Ejemplares similares

Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad
por: Bernhem, Kristoffer, et al.
Publicado: (2021)

AT(1)-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers
por: Bernhem, Kristoffer, et al.
Publicado: (2017)

Spatial distribution of Na(+)-K(+)-ATPase in dendritic spines dissected by nanoscale superresolution STED microscopy
por: Blom, Hans, et al.
Publicado: (2011)

RNA-seq reveals altered gene expression levels in proximal tubular cell cultures compared to renal cortex but not during early glucotoxicity
por: Nilsson, Linnéa M., et al.
Publicado: (2020)

Regulation of Neuronal Na,K-ATPase by Extracellular Scaffolding Proteins
por: Liebmann, Thomas, et al.
Publicado: (2018)

Spatial Distribution of DARPP-32 in Dendritic Spines
por: Blom, Hans, et al.
Publicado: (2013)

Role of Na,K-ATPase α1 and α2 Isoforms in the Support of Astrocyte Glutamate Uptake
por: Illarionava, Nina B., et al.
Publicado: (2014)

Nanoscopic spine localization of Norbin, an mGluR5 accessory protein
por: Westin, Linda, et al.
Publicado: (2014)

Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na(+), K(+)–ATPase control of cell adhesion, proliferation, and survival
por: Panizza, Elena, et al.
Publicado: (2019)

Spontaneous calcium activity in metanephric mesenchymal cells regulates branching morphogenesis in the embryonic kidney
por: Fontana, Jacopo M., et al.
Publicado: (2019)

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
por: Ghezzi, Chiara, et al.
Publicado: (2018)

Ouabain protects against adverse developmental programming of the kidney
por: Li, Juan, et al.
Publicado: (2010)

Ouabain Modulates the Functional Interaction Between Na,K-ATPase and NMDA Receptor
por: Akkuratov, Evgeny E., et al.
Publicado: (2020)

LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2
por: Powell, David R, et al.
Publicado: (2015)

Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans
por: Lu, Yasong, et al.
Publicado: (2014)

Sodium glucose cotransporter (SGLT)-2 inhibitors alleviate the renal stress responsible for sympathetic activation
por: Sano, Motoaki
Publicado: (2020)

Comparative analysis of SGLT-2 expression in renal vasculitis and lupus nephritis
por: Hakroush, Samy, et al.
Publicado: (2022)

Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk
por: Seidelmann, Sara B., et al.
Publicado: (2018)

Quantification of endogenous and exogenous protein expressions of Na,K-ATPase with super-resolution PALM/STORM imaging
por: Bernhem, Kristoffer, et al.
Publicado: (2018)

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption
por: Unno, Keiko, et al.
Publicado: (2023)

SMLocalizer, a GPU accelerated ImageJ plugin for single molecule localization microscopy
por: Bernhem, Kristoffer, et al.
Publicado: (2018)

A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells
por: Lu, Yan-Ting, et al.
Publicado: (2018)

Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?
por: Liu, Jiwen (Jim), et al.
Publicado: (2012)

Osmotic Water Transport with Glucose in GLUT2 and SGLT
por: Naftalin, Richard J.
Publicado: (2008)

SGLT2i: beyond the glucose-lowering effect
por: Ni, Lihua, et al.
Publicado: (2020)

Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors
por: Scisciola, Lucia, et al.
Publicado: (2023)

Na(+)-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
por: Gorboulev, Valentin, et al.
Publicado: (2012)

Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus)
por: Blanco, Ayelén Melisa, et al.
Publicado: (2017)

Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
por: Kalra, Sanjay, et al.
Publicado: (2015)

GI inflammation Increases Sodium-Glucose Cotransporter Sglt1
por: Park, Jiyoung, et al.
Publicado: (2019)

Using a Mathematical Modeling To Simulate Pharmacokinetics and Urinary Glucose Excretion of Luseogliflozin and Explore the Role of SGLT1/2 in Renal Glucose Reabsorption
por: Wang, Zhongjian, et al.
Publicado: (2022)

Antenatal Corticosteroids and Postnatal Fluid Restriction Produce Differential Effects on AQP3 Expression, Water Handling, and Barrier Function in Perinatal Rat Epidermis
por: Agren, Johan, et al.
Publicado: (2010)

Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
por: Zyśk, Marlena, et al.
Publicado: (2023)

Luseogliflozin, a SGLT2 Inhibitor, Does Not Affect Glucose Uptake Kinetics in Renal Proximal Tubules of Live Mice
por: Zhang, Anqi, et al.
Publicado: (2021)

Real‐time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cells
por: Ghezzi, Chiara, et al.
Publicado: (2017)

Conformational Dynamics of hSGLT1 during Na(+)/Glucose Cotransport
por: Loo, Donald D.F., et al.
Publicado: (2006)

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing
por: Röder, Pia V., et al.
Publicado: (2014)

Efficacy and Safety of the Use of SGLT2 Inhibitors in Patients on Incremental Hemodialysis: Maximizing Residual Renal Function, Is There a Role for SGLT2 Inhibitors?
por: De La Flor, José C., et al.
Publicado: (2023)

Immunohistochemical expressionof sodium-dependent glucose transporter - 2 (SGLT-2) in clear cell renal carcinoma: possible prognostic implications
por: Kobayashi, Minoru, et al.
Publicado: (2019)

SGLT2 inhibitors and renal complications in type 1 diabetes
por: Petrie, John R
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_beuchpgsqfnof5usgsupj2ebhe