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Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery

BACKGROUND: Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no o...

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Autores principales: Mu, Guang-Chuan, Huang, Yuan, Liu, Zhi-Ming, Chen, Zhi-Bai, Wu, Xiang-Hua, Qin, Xin-Gan, Zeng, Yan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580319/
https://www.ncbi.nlm.nih.gov/pubmed/31236200
http://dx.doi.org/10.4251/wjgo.v11.i6.499
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author Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Chen, Zhi-Bai
Wu, Xiang-Hua
Qin, Xin-Gan
Zeng, Yan-Jun
author_facet Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Chen, Zhi-Bai
Wu, Xiang-Hua
Qin, Xin-Gan
Zeng, Yan-Jun
author_sort Mu, Guang-Chuan
collection PubMed
description BACKGROUND: Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node around the abnormal hepatic artery derived from the superior mesenteric artery. AIM: To investigate the relationship between celiac artery variation and the number of lymph nodes dissection in gastric cancer surgery. METHODS: The clinicopathological data of 421 patients treated with radical D2 lymphadenectomy were analyzed retrospectively. The difference of the number of lymph nodes dissection between the celiac artery variation group and the normal vessels group and the relationship with prognosis were analyzed. RESULTS: Celiac artery variation was found in 110 patients, with a variation rate of 26.13%. Celiac artery variation, tumor staging, and Borrmann typing were factors that affected lymph node clearance in gastric cancer, and the number of lymph nodes dissection in patients with celiac artery variation was significantly less than that of non-variant groups (P < 0.05). Univariate analysis showed that there was no significant difference in survival time between the two groups (P > 0.05). Univariate and multiple Cox regression analysis showed that celiac artery variation was not a prognostic factor for gastric cancer (P > 0.05). Tumor staging, intraoperative bleeding, and positive lymph node ratio were prognostic factors for gastric cancer patients (all P < 0.05). CONCLUSION: The number of lymph nodes dissection in patients with celiac artery variation was reduced, but there was no obvious effect on prognosis. Therefore, lymph nodes around the abnormal hepatic artery may not need to be dissected in radical D2 lymphadenectomy.
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spelling pubmed-65803192019-06-24 Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery Mu, Guang-Chuan Huang, Yuan Liu, Zhi-Ming Chen, Zhi-Bai Wu, Xiang-Hua Qin, Xin-Gan Zeng, Yan-Jun World J Gastrointest Oncol Retrospective Study BACKGROUND: Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node around the abnormal hepatic artery derived from the superior mesenteric artery. AIM: To investigate the relationship between celiac artery variation and the number of lymph nodes dissection in gastric cancer surgery. METHODS: The clinicopathological data of 421 patients treated with radical D2 lymphadenectomy were analyzed retrospectively. The difference of the number of lymph nodes dissection between the celiac artery variation group and the normal vessels group and the relationship with prognosis were analyzed. RESULTS: Celiac artery variation was found in 110 patients, with a variation rate of 26.13%. Celiac artery variation, tumor staging, and Borrmann typing were factors that affected lymph node clearance in gastric cancer, and the number of lymph nodes dissection in patients with celiac artery variation was significantly less than that of non-variant groups (P < 0.05). Univariate analysis showed that there was no significant difference in survival time between the two groups (P > 0.05). Univariate and multiple Cox regression analysis showed that celiac artery variation was not a prognostic factor for gastric cancer (P > 0.05). Tumor staging, intraoperative bleeding, and positive lymph node ratio were prognostic factors for gastric cancer patients (all P < 0.05). CONCLUSION: The number of lymph nodes dissection in patients with celiac artery variation was reduced, but there was no obvious effect on prognosis. Therefore, lymph nodes around the abnormal hepatic artery may not need to be dissected in radical D2 lymphadenectomy. Baishideng Publishing Group Inc 2019-06-15 2019-06-15 /pmc/articles/PMC6580319/ /pubmed/31236200 http://dx.doi.org/10.4251/wjgo.v11.i6.499 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Chen, Zhi-Bai
Wu, Xiang-Hua
Qin, Xin-Gan
Zeng, Yan-Jun
Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title_full Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title_fullStr Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title_full_unstemmed Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title_short Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
title_sort relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580319/
https://www.ncbi.nlm.nih.gov/pubmed/31236200
http://dx.doi.org/10.4251/wjgo.v11.i6.499
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