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Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

BACKGROUND: Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate cells (PSCs) of the tumor stroma are known to interact with pancreatic cancer ce...

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Detalles Bibliográficos
Autores principales:	Amrutkar, Manoj, Aasrum, Monica, Verbeke, Caroline S., Gladhaug, Ivar P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580453/ https://www.ncbi.nlm.nih.gov/pubmed/31208372 http://dx.doi.org/10.1186/s12885-019-5803-1

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