Cargando…

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

BACKGROUND: Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance of cancer cells to the thera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Lu, Wang, Pan, Sun, Ying-Jian, Wu, Yi-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580523/ https://www.ncbi.nlm.nih.gov/pubmed/31215501 http://dx.doi.org/10.1186/s13046-019-1251-7

Ejemplares similares

Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer
por: Yuan, Zeting, et al.
Publicado: (2020)

Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-κB Signaling Pathway
por: Li, Ling, et al.
Publicado: (2020)

Ginsenoside panaxatriol reverses TNBC paclitaxel resistance by inhibiting the IRAK1/NF-κB and ERK pathways
por: Wang, Panpan, et al.
Publicado: (2020)

Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway
por: Sui, Hua, et al.
Publicado: (2014)

IL-22 Confers EGFR-TKI Resistance in NSCLC via the AKT and ERK Signaling Pathways
por: Wang, Xiaomeng, et al.
Publicado: (2019)

Baicalin prevents pulmonary arterial remodeling in vivo via the AKT/ERK/NF-κB signaling pathways
por: Yan, Guosen, et al.
Publicado: (2019)

Targeting TF-AKT/ERK-EGFR Pathway Suppresses the Growth of Hepatocellular Carcinoma
por: Huang, Shan-Zhou, et al.
Publicado: (2019)

Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes
por: JIANG, NING, et al.
Publicado: (2016)

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives
por: Zhang, Guoying, et al.
Publicado: (2014)

AREG mediates the epithelial-mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF-κB signalling pathway
por: Wang, Li, et al.
Publicado: (2020)

RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation
por: Cho, Jung Hee, et al.
Publicado: (2018)

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways
por: Butler, Miriam, et al.
Publicado: (2022)

Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway
por: Indramanee, Somsiri, et al.
Publicado: (2019)

Carrageenophyte Kappaphycus malesianus Inhibits Microglia-Mediated Neuroinflammation via Suppression of AKT/NF-κB and ERK Signaling Pathways
por: Lai, Nicole Jean-Yean, et al.
Publicado: (2022)

Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways
por: Zhao, Jun, et al.
Publicado: (2022)

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway
por: Tyagi, Nikhil, et al.
Publicado: (2014)

Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts
por: Miyazaki, Tsuyoshi, et al.
Publicado: (2000)

Nitric Oxide Synthase Regulates Gut Microbiota Homeostasis by ERK-NF-κB Pathway in Shrimp
por: Hong, Pan-Pan, et al.
Publicado: (2021)

IOX-101 Reverses Drug Resistance Through Suppression of Akt/mTOR/NF-κB Signaling in Cancer Stem Cell-Like, Sphere-Forming NSCLC Cell
por: Fayi, Majed Al, et al.
Publicado: (2020)

D-Limonene mitigate myocardial injury in rats through MAPK/ERK/NF-κB pathway inhibition
por: Younis, Nancy Safwat
Publicado: (2020)

Submersion and hypoxia inhibit alveolar epithelial Na(+) transport through ERK/NF-κB signaling pathway
por: Zhou, Wei, et al.
Publicado: (2023)

Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway
por: Cui, Yuehong, et al.
Publicado: (2017)

Suppression Of Aberrant Activation Of NF-κB Pathway In Drug-resistant Leukemia Stem Cells Contributes To Parthenolide-potentiated Reversal Of Drug Resistance In Leukemia
por: Yi, Juan, et al.
Publicado: (2021)

Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF-κB Pathway in Brain
por: Sevastre-Berghian, Alexandra C., et al.
Publicado: (2017)

miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway
por: HAN, JING, et al.
Publicado: (2016)

Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
por: Mostafa, Rasha E., et al.
Publicado: (2023)

Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway
por: Zhang, Yonggang, et al.
Publicado: (2019)

Peiminine Protects against Lipopolysaccharide-Induced Mastitis by Inhibiting the AKT/NF-κB, ERK1/2 and p38 Signaling Pathways
por: Gong, Qian, et al.
Publicado: (2018)

Casticin suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating the AKT/ERK and NF-κB signaling pathways
por: Yang, Fan, et al.
Publicado: (2023)

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway
por: Gupta, Subash C., et al.
Publicado: (2014)

Acquisition of EGFR TKI resistance and EMT phenotype is linked with activation of IGF1R/NF-κB pathway in EGFR-mutant NSCLC
por: Li, Ling, et al.
Publicado: (2017)

ERK-mediated NF-κB activation through ASIC1 in response to acidosis
por: Chen, B, et al.
Publicado: (2016)

RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma
por: Zhao, Weilin, et al.
Publicado: (2017)

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts
por: Zhu, Meisong, et al.
Publicado: (2022)

CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways
por: Liu, Lu, et al.
Publicado: (2021)

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway
por: Wang, Lihui, et al.
Publicado: (2018)

Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-κB Pathway
por: Zhao, Yan, et al.
Publicado: (2022)

Blockade of telomerase reverse transcriptase enhances chemosensitivity in head and neck cancers through inhibition of AKT/ ERK signaling pathways
por: Zhao, Tengda, et al.
Publicado: (2015)

The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma
por: Liu, Jin, et al.
Publicado: (2020)

LXR ligands induce apoptosis of EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt-NF-κB activation
por: Liu, Siwen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j5ds0ge0ftnp0f5uk34vlubdp1