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Neuropilin-1 drives tumor-specific uptake of chlorotoxin

BACKGROUND: Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic ((131)I-TM601) yielded promising results in human glioma clinical studies, and the imaging agent tozuleristide, is under investigation in CNS cancer...

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Detalles Bibliográficos
Autores principales:	McGonigle, Sharon, Majumder, Utpal, Kolber-Simonds, Donna, Wu, Jiayi, Hart, Andrew, Noland, Thomas, TenDyke, Karen, Custar, Daniel, Li, Danyang, Du, Hong, Postema, Maarten H. D., Lai, W. George, Twine, Natalie C., Woodall-Jappe, Mary, Nomoto, Kenichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580635/ https://www.ncbi.nlm.nih.gov/pubmed/31208428 http://dx.doi.org/10.1186/s12964-019-0368-9

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