Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and...

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Detalles Bibliográficos
Autores principales: Saha, Abhik, Robertson, Erle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Gem
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580952/
https://www.ncbi.nlm.nih.gov/pubmed/30971472
http://dx.doi.org/10.1128/JVI.00238-19
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author Saha, Abhik
Robertson, Erle S.
author_facet Saha, Abhik
Robertson, Erle S.
author_sort Saha, Abhik
collection PubMed
description Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis.
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spelling pubmed-65809522019-07-03 Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus Saha, Abhik Robertson, Erle S. J Virol Gem Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis. American Society for Microbiology 2019-06-14 /pmc/articles/PMC6580952/ /pubmed/30971472 http://dx.doi.org/10.1128/JVI.00238-19 Text en Copyright © 2019 Saha and Robertson. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Gem
Saha, Abhik
Robertson, Erle S.
Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title_full Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title_fullStr Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title_full_unstemmed Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title_short Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus
title_sort mechanisms of b-cell oncogenesis induced by epstein-barr virus
topic Gem
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580952/
https://www.ncbi.nlm.nih.gov/pubmed/30971472
http://dx.doi.org/10.1128/JVI.00238-19
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