Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA

Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of Coxiella burnetii in a patient with culture-negative endocarditis of a prosthetic pulmonar...

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Autores principales: Kondo, Maiko, Dalai, Sudeb C, Venkatasubrahmanyam, Shivkumar, Eisenberg, Nell, Robinson, Brian D, Westblade, Lars F, Marks, Kristen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580995/
https://www.ncbi.nlm.nih.gov/pubmed/31249846
http://dx.doi.org/10.1093/ofid/ofz242
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author Kondo, Maiko
Dalai, Sudeb C
Venkatasubrahmanyam, Shivkumar
Eisenberg, Nell
Robinson, Brian D
Westblade, Lars F
Marks, Kristen M
author_facet Kondo, Maiko
Dalai, Sudeb C
Venkatasubrahmanyam, Shivkumar
Eisenberg, Nell
Robinson, Brian D
Westblade, Lars F
Marks, Kristen M
author_sort Kondo, Maiko
collection PubMed
description Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of Coxiella burnetii in a patient with culture-negative endocarditis of a prosthetic pulmonary valve, enabling early targeted treatment prior to valve replacement surgery.
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spelling pubmed-65809952019-06-27 Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA Kondo, Maiko Dalai, Sudeb C Venkatasubrahmanyam, Shivkumar Eisenberg, Nell Robinson, Brian D Westblade, Lars F Marks, Kristen M Open Forum Infect Dis Brief Report Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of Coxiella burnetii in a patient with culture-negative endocarditis of a prosthetic pulmonary valve, enabling early targeted treatment prior to valve replacement surgery. Oxford University Press 2019-06-01 /pmc/articles/PMC6580995/ /pubmed/31249846 http://dx.doi.org/10.1093/ofid/ofz242 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kondo, Maiko
Dalai, Sudeb C
Venkatasubrahmanyam, Shivkumar
Eisenberg, Nell
Robinson, Brian D
Westblade, Lars F
Marks, Kristen M
Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title_full Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title_fullStr Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title_full_unstemmed Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title_short Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA
title_sort diagnosis and genotyping of coxiella burnetii endocarditis in a patient with prosthetic pulmonary valve replacement using next-generation sequencing of plasma microbial cell-free dna
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580995/
https://www.ncbi.nlm.nih.gov/pubmed/31249846
http://dx.doi.org/10.1093/ofid/ofz242
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