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pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma

Histone deacetylases (HDACs) are known to be key enzymes in cancer development and progression through their modulation of chromatin structure and the expression and post-translational modification of numerous proteins. Aggressive dedifferentiated tumors, like glioblastoma, frequently overexpress HD...

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Detalles Bibliográficos
Autores principales:	Householder, Kyle T., DiPerna, Danielle M., Chung, Eugene P., Luning, Anne Rosa, Nguyen, Duong T., Stabenfeldt, Sarah E., Mehta, Shwetal, Sirianni, Rachael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581030/ https://www.ncbi.nlm.nih.gov/pubmed/29533842 http://dx.doi.org/10.1016/j.colsurfb.2018.02.048

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