4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in facioscapulohumeral muscular dystrophy

Despite increasing insights in genome structure organization, the role of DNA repetitive elements, accounting for more than two thirds of the human genome, remains elusive. Facioscapulohumeral muscular dystrophy (FSHD) is associated with deletion of D4Z4 repeat array below 11 units at 4q35.2. It is...

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Detalles Bibliográficos
Autores principales: Cortesi, Alice, Pesant, Matthieu, Sinha, Shruti, Marasca, Federica, Sala, Eleonora, Gregoretti, Francesco, Antonelli, Laura, Oliva, Gennaro, Chiereghin, Chiara, Soldà, Giulia, Bodega, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581056/
https://www.ncbi.nlm.nih.gov/pubmed/31097473
http://dx.doi.org/10.1101/gr.233288.117

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