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Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study

BACKGROUND: Primary headache disorders (PHDs) are associated with sleep problems. It is suggested that headache and sleep disorder share anatomical and physiological characteristics. We hypothesised that patients with PHDs were exposed to a great risk for developing sleep apnoea (SA). METHODS: In th...

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Autores principales: Yin, Jiu-Haw, Chen, Shao-Yuan, Lin, Chun-Chieh, Sung, Yueh-Feng, Chou, Chung-Hsing, Chung, Chi-Hsiang, Chien, Wu-Chien, Yang, Fu-Chi, Tsai, Chia-Kuang, Tsai, Chia-Lin, Lin, Guan-Yu, Lee, Jiunn-Tay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581072/
https://www.ncbi.nlm.nih.gov/pubmed/30936249
http://dx.doi.org/10.1136/postgradmedj-2018-136220
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author Yin, Jiu-Haw
Chen, Shao-Yuan
Lin, Chun-Chieh
Sung, Yueh-Feng
Chou, Chung-Hsing
Chung, Chi-Hsiang
Chien, Wu-Chien
Yang, Fu-Chi
Tsai, Chia-Kuang
Tsai, Chia-Lin
Lin, Guan-Yu
Lee, Jiunn-Tay
author_facet Yin, Jiu-Haw
Chen, Shao-Yuan
Lin, Chun-Chieh
Sung, Yueh-Feng
Chou, Chung-Hsing
Chung, Chi-Hsiang
Chien, Wu-Chien
Yang, Fu-Chi
Tsai, Chia-Kuang
Tsai, Chia-Lin
Lin, Guan-Yu
Lee, Jiunn-Tay
author_sort Yin, Jiu-Haw
collection PubMed
description BACKGROUND: Primary headache disorders (PHDs) are associated with sleep problems. It is suggested that headache and sleep disorder share anatomical and physiological characteristics. We hypothesised that patients with PHDs were exposed to a great risk for developing sleep apnoea (SA). METHODS: In this retrospective longitudinal study, the data obtained from the Longitudinal Health Insurance Database in Taiwan were analysed. The study included 1346 patients with PHDs who were initially diagnosed and 5348 patients who were randomly selected and age/sex matched with the study group as controls. PHDs, SA, comorbidities and other confounding factors were defined based on International Classification of Diseases, Ninth Revision, Clinical Modification. Cox proportional hazards regressions were employed to examine adjusted HRs after adjusting with confounding factors. RESULTS: Our data revealed that patients with PHDs had a higher risk (HR 2.17, 95% CI 1.259 to 3.739, p<0.05) to develop SA compared with matched cohorts, whereas patients with migraine exhibited a high risk (HR 2.553, 95% CI 1.460 to 4.395, p<0.01). The results showed that patients with PHDs aged 18–44 exhibited highest risk of developing SA. In addition, males with PHDs exhibited an HR 3.159 (95% CI 1.479 to 6.749, p<0.01) for developing SA, respectively. The impact of PHDs on SA risk was progressively increased by various follow-up time intervals. CONCLUSION: Our results suggest that PHDs are linked to an increased risk for SA with sex-dependent and time-dependent characteristics.
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spelling pubmed-65810722019-07-02 Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study Yin, Jiu-Haw Chen, Shao-Yuan Lin, Chun-Chieh Sung, Yueh-Feng Chou, Chung-Hsing Chung, Chi-Hsiang Chien, Wu-Chien Yang, Fu-Chi Tsai, Chia-Kuang Tsai, Chia-Lin Lin, Guan-Yu Lee, Jiunn-Tay Postgrad Med J Original Article BACKGROUND: Primary headache disorders (PHDs) are associated with sleep problems. It is suggested that headache and sleep disorder share anatomical and physiological characteristics. We hypothesised that patients with PHDs were exposed to a great risk for developing sleep apnoea (SA). METHODS: In this retrospective longitudinal study, the data obtained from the Longitudinal Health Insurance Database in Taiwan were analysed. The study included 1346 patients with PHDs who were initially diagnosed and 5348 patients who were randomly selected and age/sex matched with the study group as controls. PHDs, SA, comorbidities and other confounding factors were defined based on International Classification of Diseases, Ninth Revision, Clinical Modification. Cox proportional hazards regressions were employed to examine adjusted HRs after adjusting with confounding factors. RESULTS: Our data revealed that patients with PHDs had a higher risk (HR 2.17, 95% CI 1.259 to 3.739, p<0.05) to develop SA compared with matched cohorts, whereas patients with migraine exhibited a high risk (HR 2.553, 95% CI 1.460 to 4.395, p<0.01). The results showed that patients with PHDs aged 18–44 exhibited highest risk of developing SA. In addition, males with PHDs exhibited an HR 3.159 (95% CI 1.479 to 6.749, p<0.01) for developing SA, respectively. The impact of PHDs on SA risk was progressively increased by various follow-up time intervals. CONCLUSION: Our results suggest that PHDs are linked to an increased risk for SA with sex-dependent and time-dependent characteristics. BMJ Publishing Group 2019-02 2019-04-01 /pmc/articles/PMC6581072/ /pubmed/30936249 http://dx.doi.org/10.1136/postgradmedj-2018-136220 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Article
Yin, Jiu-Haw
Chen, Shao-Yuan
Lin, Chun-Chieh
Sung, Yueh-Feng
Chou, Chung-Hsing
Chung, Chi-Hsiang
Chien, Wu-Chien
Yang, Fu-Chi
Tsai, Chia-Kuang
Tsai, Chia-Lin
Lin, Guan-Yu
Lee, Jiunn-Tay
Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title_full Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title_fullStr Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title_full_unstemmed Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title_short Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
title_sort increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581072/
https://www.ncbi.nlm.nih.gov/pubmed/30936249
http://dx.doi.org/10.1136/postgradmedj-2018-136220
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