HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking selectivity for IN tetramers versus lower order p...

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Detalles Bibliográficos
Autores principales: Koneru, Pratibha C, Francis, Ashwanth C, Deng, Nanjie, Rebensburg, Stephanie V, Hoyte, Ashley C, Lindenberger, Jared, Adu-Ampratwum, Daniel, Larue, Ross C, Wempe, Michael F, Engelman, Alan N, Lyumkis, Dmitry, Fuchs, James R, Levy, Ronald M, Melikyan, Gregory B, Kvaratskhelia, Mamuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581505/
https://www.ncbi.nlm.nih.gov/pubmed/31120420
http://dx.doi.org/10.7554/eLife.46344

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