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Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?

The liver is the main metabolic organ in the body, serving as a significant hormonal secretory gland and functioning to maintain hormone balance and homeostasis. Steroid hormones regulate various biological pathways, mainly in the reproductive system and in many metabolic processes. The liver, as we...

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Autores principales: Charni-Natan, Meital, Aloni-Grinstein, Ronit, Osher, Etty, Rotter, Varda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581675/
https://www.ncbi.nlm.nih.gov/pubmed/31244779
http://dx.doi.org/10.3389/fendo.2019.00374
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author Charni-Natan, Meital
Aloni-Grinstein, Ronit
Osher, Etty
Rotter, Varda
author_facet Charni-Natan, Meital
Aloni-Grinstein, Ronit
Osher, Etty
Rotter, Varda
author_sort Charni-Natan, Meital
collection PubMed
description The liver is the main metabolic organ in the body, serving as a significant hormonal secretory gland and functioning to maintain hormone balance and homeostasis. Steroid hormones regulate various biological pathways, mainly in the reproductive system and in many metabolic processes. The liver, as well as steroid hormones, contribute significantly, through functional intertwine, to homeostasis maintenance, and proper responses during stress. Malfunction of either has a significant impact on the other and may lead to severe liver diseases as well as to several endocrine syndromes. Thus, the regulation on liver functions as on steroid hormones levels and activities is well-controlled. p53, the well-known tumor suppressor gene, was recently found to regulate metabolism and general homeostasis processes, particularly within the liver. Moreover, p53 was shown to be involved in steroid hormones regulation. In this review, we discuss the bi-directional regulation of the liver and the steroid hormones pointing to p53 as a novel regulator in this axis. A comprehensive understanding of the molecular mechanisms of this axis may help to prevent and treat related disease, especially with the increasing exposure of the population to environmental steroid hormones and steroid hormone-based medication.
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spelling pubmed-65816752019-06-26 Liver and Steroid Hormones—Can a Touch of p53 Make a Difference? Charni-Natan, Meital Aloni-Grinstein, Ronit Osher, Etty Rotter, Varda Front Endocrinol (Lausanne) Endocrinology The liver is the main metabolic organ in the body, serving as a significant hormonal secretory gland and functioning to maintain hormone balance and homeostasis. Steroid hormones regulate various biological pathways, mainly in the reproductive system and in many metabolic processes. The liver, as well as steroid hormones, contribute significantly, through functional intertwine, to homeostasis maintenance, and proper responses during stress. Malfunction of either has a significant impact on the other and may lead to severe liver diseases as well as to several endocrine syndromes. Thus, the regulation on liver functions as on steroid hormones levels and activities is well-controlled. p53, the well-known tumor suppressor gene, was recently found to regulate metabolism and general homeostasis processes, particularly within the liver. Moreover, p53 was shown to be involved in steroid hormones regulation. In this review, we discuss the bi-directional regulation of the liver and the steroid hormones pointing to p53 as a novel regulator in this axis. A comprehensive understanding of the molecular mechanisms of this axis may help to prevent and treat related disease, especially with the increasing exposure of the population to environmental steroid hormones and steroid hormone-based medication. Frontiers Media S.A. 2019-06-12 /pmc/articles/PMC6581675/ /pubmed/31244779 http://dx.doi.org/10.3389/fendo.2019.00374 Text en Copyright © 2019 Charni-Natan, Aloni-Grinstein, Osher and Rotter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Charni-Natan, Meital
Aloni-Grinstein, Ronit
Osher, Etty
Rotter, Varda
Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title_full Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title_fullStr Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title_full_unstemmed Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title_short Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
title_sort liver and steroid hormones—can a touch of p53 make a difference?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581675/
https://www.ncbi.nlm.nih.gov/pubmed/31244779
http://dx.doi.org/10.3389/fendo.2019.00374
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