Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary effector T cells and at the T cell-antigen-presenting cell i...

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Detalles Bibliográficos
Autores principales: Celis-Gutierrez, Javier, Blattmann, Peter, Zhai, Yunhao, Jarmuzynski, Nicolas, Ruminski, Kilian, Grégoire, Claude, Ounoughene, Youcef, Fiore, Frédéric, Aebersold, Ruedi, Roncagalli, Romain, Gstaiger, Matthias, Malissen, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581740/
https://www.ncbi.nlm.nih.gov/pubmed/31189114
http://dx.doi.org/10.1016/j.celrep.2019.05.041

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