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Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes

Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson’s disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathog...

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Autores principales: Singh, Amrendra Pratap, Ramana, G., Bajaj, Teena, Singh, Vishwajeet, Dwivedi, Sadanand, Behari, Madhuri, Dey, A. B., Dey, Sharmistha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581755/
https://www.ncbi.nlm.nih.gov/pubmed/31244600
http://dx.doi.org/10.3389/fnmol.2019.00129
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author Singh, Amrendra Pratap
Ramana, G.
Bajaj, Teena
Singh, Vishwajeet
Dwivedi, Sadanand
Behari, Madhuri
Dey, A. B.
Dey, Sharmistha
author_facet Singh, Amrendra Pratap
Ramana, G.
Bajaj, Teena
Singh, Vishwajeet
Dwivedi, Sadanand
Behari, Madhuri
Dey, A. B.
Dey, Sharmistha
author_sort Singh, Amrendra Pratap
collection PubMed
description Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson’s disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with Sirtuin (SIRT)2 proteins for modulating PD. We aimed to evaluate SIRT protein expression in serum of PD patients and compare it with APSs and normal elderly control (GC) and to correlate this with α-Syn. SIRT protein expression was evaluated in sera of 68 PD; 34 APS and 68 GC without any neuro-psychiatric illness as controls by surface plasmon resonance (SPR). SIRT2 expression was correlated with α-Syn in PD and GC. Significant (p < 0.0001) differences were observed between serum SIRT2 concentration in PD and APS and GC as well as between APS and GC. Receiver operating characteristic (ROC) analysis revealed the strong cut-off value to differentiate PD from APS and GC and also APS from GC. Significant correlation was observed among SIRT2 levels in early PD patients with Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn & Yahr (H & Y) and increased duration of disease. In addition, a strong positive correlation of SIRT2 with α-Syn (p < 0.0001) was observed. However, no such difference was detected for serum SIRT1 in cases of PD and APS or for GC. The present study is the first to report elevated serum SIRT2 in PD. The study also provided a simple test to distinguish PD from APS and may have translational utility for diagnosis.
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spelling pubmed-65817552019-06-26 Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes Singh, Amrendra Pratap Ramana, G. Bajaj, Teena Singh, Vishwajeet Dwivedi, Sadanand Behari, Madhuri Dey, A. B. Dey, Sharmistha Front Mol Neurosci Neuroscience Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson’s disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with Sirtuin (SIRT)2 proteins for modulating PD. We aimed to evaluate SIRT protein expression in serum of PD patients and compare it with APSs and normal elderly control (GC) and to correlate this with α-Syn. SIRT protein expression was evaluated in sera of 68 PD; 34 APS and 68 GC without any neuro-psychiatric illness as controls by surface plasmon resonance (SPR). SIRT2 expression was correlated with α-Syn in PD and GC. Significant (p < 0.0001) differences were observed between serum SIRT2 concentration in PD and APS and GC as well as between APS and GC. Receiver operating characteristic (ROC) analysis revealed the strong cut-off value to differentiate PD from APS and GC and also APS from GC. Significant correlation was observed among SIRT2 levels in early PD patients with Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn & Yahr (H & Y) and increased duration of disease. In addition, a strong positive correlation of SIRT2 with α-Syn (p < 0.0001) was observed. However, no such difference was detected for serum SIRT1 in cases of PD and APS or for GC. The present study is the first to report elevated serum SIRT2 in PD. The study also provided a simple test to distinguish PD from APS and may have translational utility for diagnosis. Frontiers Media S.A. 2019-06-12 /pmc/articles/PMC6581755/ /pubmed/31244600 http://dx.doi.org/10.3389/fnmol.2019.00129 Text en Copyright © 2019 Singh, Ramana, Bajaj, Singh, Dwivedi, Behari, Dey and Dey. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Singh, Amrendra Pratap
Ramana, G.
Bajaj, Teena
Singh, Vishwajeet
Dwivedi, Sadanand
Behari, Madhuri
Dey, A. B.
Dey, Sharmistha
Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title_full Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title_fullStr Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title_full_unstemmed Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title_short Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian Syndromes
title_sort elevated serum sirt 2 may differentiate parkinson’s disease from atypical parkinsonian syndromes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581755/
https://www.ncbi.nlm.nih.gov/pubmed/31244600
http://dx.doi.org/10.3389/fnmol.2019.00129
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