PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most frequent type of dementia in older people. The complex nature of AD calls for the development of multitarget agents addressing key pathogenic processes. Donepezil, an acetylcholinesterase inhibitor, is a first-line acetylcholinesterase inhibitor used for the trea...

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Detalles Bibliográficos
Autores principales: Morroni, Fabiana, Sita, Giulia, Graziosi, Agnese, Ravegnini, Gloria, Molteni, Raffaella, Paladini, Maria Serena, Dias, Kris Simone Tranches, dos Santos, Ariele Faria, Viegas, Claudio, Camps, Ihosvany, Pruccoli, Letizia, Tarozzi, Andrea, Hrelia, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581760/
https://www.ncbi.nlm.nih.gov/pubmed/31244664
http://dx.doi.org/10.3389/fphar.2019.00658

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