Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

Trypanothione (T(SH)(2)) is the main antioxidant metabolite for peroxide reduction in Trypanosoma cruzi; therefore, its metabolism has attracted attention for therapeutic intervention against Chagas disease. To validate drug targets within the T(SH)(2) metabolism, the strategies and methods of Metab...

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Detalles Bibliográficos
Autores principales: González-Chávez, Zabdi, Vázquez, Citlali, Mejia-Tlachi, Marlen, Márquez-Dueñas, Claudia, Manning-Cela, Rebeca, Encalada, Rusely, Rodríguez-Enríquez, Sara, Michels, Paul A.M., Moreno-Sánchez, Rafael, Saavedra, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581782/
https://www.ncbi.nlm.nih.gov/pubmed/31203195
http://dx.doi.org/10.1016/j.redox.2019.101231

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