Progress update from the hippocampal subfields group

INTRODUCTION: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence...

Descripción completa

Detalles Bibliográficos
Autores principales: Olsen, Rosanna K., Carr, Valerie A., Daugherty, Ana M., La Joie, Renaud, Amaral, Robert S.C., Amunts, Katrin, Augustinack, Jean C., Bakker, Arnold, Bender, Andrew R., Berron, David, Boccardi, Marina, Bocchetta, Martina, Burggren, Alison C., Chakravarty, M. Mallar, Chételat, Gaël, de Flores, Robin, DeKraker, Jordan, Ding, Song-Lin, Geerlings, Mirjam I., Huang, Yushan, Insausti, Ricardo, Johnson, Elliott G., Kanel, Prabesh, Kedo, Olga, Kennedy, Kristen M., Keresztes, Attila, Lee, Joshua K., Lindenberger, Ulman, Mueller, Susanne G., Mulligan, Elizabeth M., Ofen, Noa, Palombo, Daniela J., Pasquini, Lorenzo, Pluta, John, Raz, Naftali, Rodrigue, Karen M., Schlichting, Margaret L., Lee Shing, Yee, Stark, Craig E.L., Steve, Trevor A., Suthana, Nanthia A., Wang, Lei, Werkle-Bergner, Markus, Yushkevich, Paul A., Yu, Qijing, Wisse, Laura E.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Special Section: Brain Imaging Working Group Summaries for the European Joint Programme for Neurodegenerative Disease Research (JPND). (Guest Editors: Jorge Jovicich & Giovanni B. Frisoni)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581847/
https://www.ncbi.nlm.nih.gov/pubmed/31245529
http://dx.doi.org/10.1016/j.dadm.2019.04.001
Descripción
Sumario:INTRODUCTION: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. METHODS: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. RESULTS: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. DISCUSSION: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Ejemplares similares