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Cell therapy for spinal cord injury using induced pluripotent stem cells

For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the t...

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Detalles Bibliográficos
Autores principales: Nagoshi, Narihito, Tsuji, Osahiko, Nakamura, Masaya, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581851/
https://www.ncbi.nlm.nih.gov/pubmed/31245451
http://dx.doi.org/10.1016/j.reth.2019.05.006
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author Nagoshi, Narihito
Tsuji, Osahiko
Nakamura, Masaya
Okano, Hideyuki
author_facet Nagoshi, Narihito
Tsuji, Osahiko
Nakamura, Masaya
Okano, Hideyuki
author_sort Nagoshi, Narihito
collection PubMed
description For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.
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spelling pubmed-65818512019-06-26 Cell therapy for spinal cord injury using induced pluripotent stem cells Nagoshi, Narihito Tsuji, Osahiko Nakamura, Masaya Okano, Hideyuki Regen Ther Review Article For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications. Japanese Society for Regenerative Medicine 2019-06-13 /pmc/articles/PMC6581851/ /pubmed/31245451 http://dx.doi.org/10.1016/j.reth.2019.05.006 Text en © 2019 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Nagoshi, Narihito
Tsuji, Osahiko
Nakamura, Masaya
Okano, Hideyuki
Cell therapy for spinal cord injury using induced pluripotent stem cells
title Cell therapy for spinal cord injury using induced pluripotent stem cells
title_full Cell therapy for spinal cord injury using induced pluripotent stem cells
title_fullStr Cell therapy for spinal cord injury using induced pluripotent stem cells
title_full_unstemmed Cell therapy for spinal cord injury using induced pluripotent stem cells
title_short Cell therapy for spinal cord injury using induced pluripotent stem cells
title_sort cell therapy for spinal cord injury using induced pluripotent stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581851/
https://www.ncbi.nlm.nih.gov/pubmed/31245451
http://dx.doi.org/10.1016/j.reth.2019.05.006
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