Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli

E3 cullin-RING ubiquitin ligase (CRL) complexes recognize specific substrates and are activated by covalent modification with ubiquitin-like Nedd8. Deneddylation inactivates CRLs and allows Cand1/A to bind and exchange substrate recognition subunits. Human as well as most fungi possess a single gene...

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Detalles Bibliográficos
Autores principales: Köhler, Anna M., Harting, Rebekka, Langeneckert, Annika E., Valerius, Oliver, Gerke, Jennifer, Meister, Cindy, Strohdiek, Anja, Braus, Gerhard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581859/
https://www.ncbi.nlm.nih.gov/pubmed/31213557
http://dx.doi.org/10.1128/mBio.01094-19

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