The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis

Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochroma...

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Autores principales: Cheng, Shiliang, Han, Jiae, Huang, Yidan, Yan, Qin, Lu, Gang, Yuan, Zuowei, Huang, Guanjun, Zheng, Jian, Liu, Tianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581873/
https://www.ncbi.nlm.nih.gov/pubmed/31245642
http://dx.doi.org/10.1016/j.heliyon.2019.e01899
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author Cheng, Shiliang
Han, Jiae
Huang, Yidan
Yan, Qin
Lu, Gang
Yuan, Zuowei
Huang, Guanjun
Zheng, Jian
Liu, Tianqiang
author_facet Cheng, Shiliang
Han, Jiae
Huang, Yidan
Yan, Qin
Lu, Gang
Yuan, Zuowei
Huang, Guanjun
Zheng, Jian
Liu, Tianqiang
author_sort Cheng, Shiliang
collection PubMed
description Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochromatographic test kit for GBS detection. The test of bacteria and culture media revealed the correlation between Sip protein expression and diagnosis discrepancy, which has never been reported. Furthermore, not only the surface accessibility of the Sip protein may vary from strains or serotypes; the secretion level of Sip protein may also vary.
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spelling pubmed-65818732019-06-26 The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis Cheng, Shiliang Han, Jiae Huang, Yidan Yan, Qin Lu, Gang Yuan, Zuowei Huang, Guanjun Zheng, Jian Liu, Tianqiang Heliyon Article Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochromatographic test kit for GBS detection. The test of bacteria and culture media revealed the correlation between Sip protein expression and diagnosis discrepancy, which has never been reported. Furthermore, not only the surface accessibility of the Sip protein may vary from strains or serotypes; the secretion level of Sip protein may also vary. Elsevier 2019-06-12 /pmc/articles/PMC6581873/ /pubmed/31245642 http://dx.doi.org/10.1016/j.heliyon.2019.e01899 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Cheng, Shiliang
Han, Jiae
Huang, Yidan
Yan, Qin
Lu, Gang
Yuan, Zuowei
Huang, Guanjun
Zheng, Jian
Liu, Tianqiang
The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_full The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_fullStr The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_full_unstemmed The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_short The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_sort correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581873/
https://www.ncbi.nlm.nih.gov/pubmed/31245642
http://dx.doi.org/10.1016/j.heliyon.2019.e01899
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