Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma

Mucormycosis is a rare but potentially mortal opportunistic infection caused by Mucorales. We present a case of rhinoorbital mucormycosis in an 11-year old male with neuroblastoma successfully treated with aggressive surgical debridement and antifungal combination of liposomal amphotericin B and pos...

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Autores principales: Athanasiadou, Kleoniki I., Athanasiadis, Dimitrios I., Constantinidis, John, Anastasiou, Athanasia, Roilides, Emmanuel, Papakonstantinou, Evgenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582074/
https://www.ncbi.nlm.nih.gov/pubmed/31245270
http://dx.doi.org/10.1016/j.mmcr.2019.06.003
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author Athanasiadou, Kleoniki I.
Athanasiadis, Dimitrios I.
Constantinidis, John
Anastasiou, Athanasia
Roilides, Emmanuel
Papakonstantinou, Evgenia
author_facet Athanasiadou, Kleoniki I.
Athanasiadis, Dimitrios I.
Constantinidis, John
Anastasiou, Athanasia
Roilides, Emmanuel
Papakonstantinou, Evgenia
author_sort Athanasiadou, Kleoniki I.
collection PubMed
description Mucormycosis is a rare but potentially mortal opportunistic infection caused by Mucorales. We present a case of rhinoorbital mucormycosis in an 11-year old male with neuroblastoma successfully treated with aggressive surgical debridement and antifungal combination of liposomal amphotericin B and posaconazole. Our patient developed signs of paranasal sinus infection and culture of fine needle biopsy grew Rhizopus arrhizus. Prompt treatment and drastic surgical resection led to complete clinical and radiological recovery without evidence of mucormycosis relapse.
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spelling pubmed-65820742019-06-26 Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma Athanasiadou, Kleoniki I. Athanasiadis, Dimitrios I. Constantinidis, John Anastasiou, Athanasia Roilides, Emmanuel Papakonstantinou, Evgenia Med Mycol Case Rep Case Report Mucormycosis is a rare but potentially mortal opportunistic infection caused by Mucorales. We present a case of rhinoorbital mucormycosis in an 11-year old male with neuroblastoma successfully treated with aggressive surgical debridement and antifungal combination of liposomal amphotericin B and posaconazole. Our patient developed signs of paranasal sinus infection and culture of fine needle biopsy grew Rhizopus arrhizus. Prompt treatment and drastic surgical resection led to complete clinical and radiological recovery without evidence of mucormycosis relapse. Elsevier 2019-06-08 /pmc/articles/PMC6582074/ /pubmed/31245270 http://dx.doi.org/10.1016/j.mmcr.2019.06.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Athanasiadou, Kleoniki I.
Athanasiadis, Dimitrios I.
Constantinidis, John
Anastasiou, Athanasia
Roilides, Emmanuel
Papakonstantinou, Evgenia
Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title_full Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title_fullStr Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title_full_unstemmed Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title_short Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
title_sort successful treatment of rhinoorbital mucormycosis due to rhizopus arrhizus with liposomal amphotericin b, posaconazole and surgical debridement in a child with neuroblastoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582074/
https://www.ncbi.nlm.nih.gov/pubmed/31245270
http://dx.doi.org/10.1016/j.mmcr.2019.06.003
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