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Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth
Bifidobacteria are one of the most abundant bacterial groups in the infant gut microbiota and are closely associated with infant health and can potentially affect health in later life. However, the details regarding the source of bifidobacteria have yet to be completely elucidated. This study aimed...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582144/ https://www.ncbi.nlm.nih.gov/pubmed/31213639 http://dx.doi.org/10.1038/s41598-019-45198-9 |
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author | Toda, Kazuya Hisata, Ken Satoh, Takumi Katsumata, Noriko Odamaki, Toshitaka Mitsuyama, Eri Katayama, Takane Kuhara, Tetsuya Aisaka, Kohzo Shimizu, Toshiaki Xiao, Jin-zhong |
author_facet | Toda, Kazuya Hisata, Ken Satoh, Takumi Katsumata, Noriko Odamaki, Toshitaka Mitsuyama, Eri Katayama, Takane Kuhara, Tetsuya Aisaka, Kohzo Shimizu, Toshiaki Xiao, Jin-zhong |
author_sort | Toda, Kazuya |
collection | PubMed |
description | Bifidobacteria are one of the most abundant bacterial groups in the infant gut microbiota and are closely associated with infant health and can potentially affect health in later life. However, the details regarding the source of bifidobacteria have yet to be completely elucidated. This study aimed to assess neonatal oral fluid (OF) as a transmission route for bifidobacteria to the infant gut during delivery. Neonatal OF and infant feces (IF) were collected immediately and one month after birth from 15 healthy vaginally delivered newborns. Bifidobacterium strains were isolated from OF and IF samples, and the similarity of strains between the OF-IF pairs was evaluated based on the average nucleotide identity (ANI) value. The 16S rRNA gene sequencing results revealed the presence of Bifidobacteriaceae at >1% relative abundance in all OF samples. Bifidobacterium strains were isolated from OF (9/15) and IF (11/15) samples, and those sharing high genomic homology (ANI values >99.5%) between the neonatal OF and IF samples were present in one-third of the OF-IF pairs. The results of this study indicate that viable bifidobacteria are present in neonatal OF and that OF at birth is a possible transmission route of bifidobacteria to the infant gut. |
format | Online Article Text |
id | pubmed-6582144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65821442019-06-26 Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth Toda, Kazuya Hisata, Ken Satoh, Takumi Katsumata, Noriko Odamaki, Toshitaka Mitsuyama, Eri Katayama, Takane Kuhara, Tetsuya Aisaka, Kohzo Shimizu, Toshiaki Xiao, Jin-zhong Sci Rep Article Bifidobacteria are one of the most abundant bacterial groups in the infant gut microbiota and are closely associated with infant health and can potentially affect health in later life. However, the details regarding the source of bifidobacteria have yet to be completely elucidated. This study aimed to assess neonatal oral fluid (OF) as a transmission route for bifidobacteria to the infant gut during delivery. Neonatal OF and infant feces (IF) were collected immediately and one month after birth from 15 healthy vaginally delivered newborns. Bifidobacterium strains were isolated from OF and IF samples, and the similarity of strains between the OF-IF pairs was evaluated based on the average nucleotide identity (ANI) value. The 16S rRNA gene sequencing results revealed the presence of Bifidobacteriaceae at >1% relative abundance in all OF samples. Bifidobacterium strains were isolated from OF (9/15) and IF (11/15) samples, and those sharing high genomic homology (ANI values >99.5%) between the neonatal OF and IF samples were present in one-third of the OF-IF pairs. The results of this study indicate that viable bifidobacteria are present in neonatal OF and that OF at birth is a possible transmission route of bifidobacteria to the infant gut. Nature Publishing Group UK 2019-06-18 /pmc/articles/PMC6582144/ /pubmed/31213639 http://dx.doi.org/10.1038/s41598-019-45198-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Toda, Kazuya Hisata, Ken Satoh, Takumi Katsumata, Noriko Odamaki, Toshitaka Mitsuyama, Eri Katayama, Takane Kuhara, Tetsuya Aisaka, Kohzo Shimizu, Toshiaki Xiao, Jin-zhong Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title | Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title_full | Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title_fullStr | Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title_full_unstemmed | Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title_short | Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
title_sort | neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582144/ https://www.ncbi.nlm.nih.gov/pubmed/31213639 http://dx.doi.org/10.1038/s41598-019-45198-9 |
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