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DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET) family enzymes, which are α-ketoglutarate (α-KG)...

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Detalles Bibliográficos
Autores principales:	Bian, Ke, Lenz, Stefan A P, Tang, Qi, Chen, Fangyi, Qi, Rui, Jost, Marco, Drennan, Catherine L, Essigmann, John M, Wetmore, Stacey D, Li, Deyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582317/ https://www.ncbi.nlm.nih.gov/pubmed/31114894 http://dx.doi.org/10.1093/nar/gkz395

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