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A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities

Resistance to androgen receptor (AR)-targeted therapies in prostate cancer (PC) is a major clinical problem. A key mechanism of treatment resistance in advanced PC is the generation of alternatively spliced forms of the AR termed AR variants (AR-Vs) that are refractory to targeted agents and drive t...

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Detalles Bibliográficos
Autores principales:	Kounatidou, Evangelia, Nakjang, Sirintra, McCracken, Stuart R C, Dehm, Scott M, Robson, Craig N, Jones, Dominic, Gaughan, Luke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582326/ https://www.ncbi.nlm.nih.gov/pubmed/31006810 http://dx.doi.org/10.1093/nar/gkz286

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