Targeted amplification of a sequence of interest in artificial chromosome in mammalian cells

A plasmid with a replication initiation region (IR) and a matrix attachment region (MAR) initiates gene amplification in mammalian cells at a random chromosomal location. A mouse artificial chromosome (MAC) vector can stably carry a large genomic region. In this study we combined these two technolog...

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Detalles Bibliográficos
Autores principales: Asoshina, Manami, Myo, Genki, Tada, Natsuko, Tajino, Koji, Shimizu, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582328/
https://www.ncbi.nlm.nih.gov/pubmed/31062017
http://dx.doi.org/10.1093/nar/gkz343

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