Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins

Inspired by DNA mimic proteins, we have introduced aromatic foldamers bearing phosphonate groups as synthetic mimics of the charge surface of B-DNA and competitive inhibitors of some therapeutically relevant DNA-binding enzymes: the human DNA Topoisomerase 1 (Top1) and the human HIV-1 integrase (HIV...

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Detalles Bibliográficos
Autores principales: Corvaglia, Valentina, Carbajo, Daniel, Prabhakaran, Panchami, Ziach, Krzysztof, Mandal, Pradeep Kumar, Santos, Victor Dos, Legeay, Carole, Vogel, Rachel, Parissi, Vincent, Pourquier, Philippe, Huc, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582331/
https://www.ncbi.nlm.nih.gov/pubmed/31073604
http://dx.doi.org/10.1093/nar/gkz352

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