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Structure-guided post-SELEX optimization of an ochratoxin A aptamer

SELEX is the cornerstone for aptamer research with broad applications in biosensors and medicine. To improve the affinity of selected aptamers, we propose a structure-guided post-SELEX approach, an optimization method based on the precise secondary structure of the aptamer–ligand complex. We demonst...

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Detalles Bibliográficos
Autores principales:	Xu, Guohua, Zhao, Jiajing, Liu, Na, Yang, Minghui, Zhao, Qiang, Li, Conggang, Liu, Maili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582339/ https://www.ncbi.nlm.nih.gov/pubmed/31062016 http://dx.doi.org/10.1093/nar/gkz336

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