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Structure-guided post-SELEX optimization of an ochratoxin A aptamer
SELEX is the cornerstone for aptamer research with broad applications in biosensors and medicine. To improve the affinity of selected aptamers, we propose a structure-guided post-SELEX approach, an optimization method based on the precise secondary structure of the aptamer–ligand complex. We demonst...
Autores principales: | Xu, Guohua, Zhao, Jiajing, Liu, Na, Yang, Minghui, Zhao, Qiang, Li, Conggang, Liu, Maili |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582339/ https://www.ncbi.nlm.nih.gov/pubmed/31062016 http://dx.doi.org/10.1093/nar/gkz336 |
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