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Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ

DNA polymerase ϵ (Pol ϵ), the major leading-strand DNA polymerase in eukaryotes, has a catalytic subunit (Pol2) and three non-catalytic subunits. The N-terminal half of Pol2 (Pol2(CORE)) exhibits both polymerase and exonuclease activity. It has been suggested that both the non-catalytic C-terminal d...

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Detalles Bibliográficos
Autores principales:	ter Beek, Josy, Parkash, Vimal, Bylund, Göran O, Osterman, Pia, Sauer-Eriksson, A Elisabeth, Johansson, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582351/ https://www.ncbi.nlm.nih.gov/pubmed/30968138 http://dx.doi.org/10.1093/nar/gkz248

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