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Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase

Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic‐N‐carboxamide FAAH inhibitors that have a good alignment of potency, metabolic stability and selectivity...

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Detalles Bibliográficos
Autores principales:	Kiss, László E., Beliaev, Alexandre, Ferreira, Humberto S., Rosa, Carla P., Bonifácio, Maria João, Loureiro, Ana I., Pires, Nuno M., Palma, P. Nuno, Soares‐da‐Silva, Patrício
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582431/ https://www.ncbi.nlm.nih.gov/pubmed/30113139 http://dx.doi.org/10.1002/cmdc.201800393

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