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Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

BACKGROUND: The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has been therapeutically targeted, yet tyrosine kinase inhibitors (TKIs) do not inhibi...

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Detalles Bibliográficos
Autores principales: Maisel, Sabrina A., Broka, Derrick, Atwell, Benjamin, Bunch, Thomas, Kupp, Robert, Singh, Shiv K., Mehta, Shwetal, Schroeder, Joyce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582486/
https://www.ncbi.nlm.nih.gov/pubmed/31215437
http://dx.doi.org/10.1186/s12967-019-1939-7