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Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status

BACKGROUND: CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features. METHODS: Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59...

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Autores principales: Liu, Zhenyin, Liu, Hongsheng, Liu, Zhenqing, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582578/
https://www.ncbi.nlm.nih.gov/pubmed/31215432
http://dx.doi.org/10.1186/s12883-019-1362-y
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author Liu, Zhenyin
Liu, Hongsheng
Liu, Zhenqing
Zhang, Jing
author_facet Liu, Zhenyin
Liu, Hongsheng
Liu, Zhenqing
Zhang, Jing
author_sort Liu, Zhenyin
collection PubMed
description BACKGROUND: CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features. METHODS: Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis. RESULTS: In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all p < 0.05). A multivariate logistic regression analysis identified that seizure history (no vs. yes odd ratio [OR]: 28.960, 95 confidence interval [CI]:2.625–319.49, p = 0.006) and SVZ involvement (SVZ- vs. SVZ+ OR: 77.092, p = 0.003; 95% CI: 4.578–1298.334) were associated with a higher incidence of CIC mutation status. The nomogram showed good discrimination, with a C-index of 0.906 (95% CI: 0.812–1.000) and was well calibrated. SVZ- group has increased (SVZ- vs. SVZ+, hazard ratio [HR]: 4.500, p = 0.04; 95% CI: 1.069–18.945) overall survival. CONCLUSIONS: Absence of seizure history and SVZ involvement (−) was associated with a higher incidence of CIC mutation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-019-1362-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-65825782019-06-26 Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status Liu, Zhenyin Liu, Hongsheng Liu, Zhenqing Zhang, Jing BMC Neurol Research Article BACKGROUND: CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features. METHODS: Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis. RESULTS: In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all p < 0.05). A multivariate logistic regression analysis identified that seizure history (no vs. yes odd ratio [OR]: 28.960, 95 confidence interval [CI]:2.625–319.49, p = 0.006) and SVZ involvement (SVZ- vs. SVZ+ OR: 77.092, p = 0.003; 95% CI: 4.578–1298.334) were associated with a higher incidence of CIC mutation status. The nomogram showed good discrimination, with a C-index of 0.906 (95% CI: 0.812–1.000) and was well calibrated. SVZ- group has increased (SVZ- vs. SVZ+, hazard ratio [HR]: 4.500, p = 0.04; 95% CI: 1.069–18.945) overall survival. CONCLUSIONS: Absence of seizure history and SVZ involvement (−) was associated with a higher incidence of CIC mutation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-019-1362-y) contains supplementary material, which is available to authorized users. BioMed Central 2019-06-18 /pmc/articles/PMC6582578/ /pubmed/31215432 http://dx.doi.org/10.1186/s12883-019-1362-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Liu, Zhenyin
Liu, Hongsheng
Liu, Zhenqing
Zhang, Jing
Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title_full Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title_fullStr Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title_full_unstemmed Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title_short Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status
title_sort oligodendroglial tumours: subventricular zone involvement and seizure history are associated with cic mutation status
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582578/
https://www.ncbi.nlm.nih.gov/pubmed/31215432
http://dx.doi.org/10.1186/s12883-019-1362-y
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