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Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia

Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in...

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Autores principales: Fenner, Amberlynn S., Webster, Kimberly T., Ficek, Bronte N., Frangakis, Constantine E., Tsapkini, Kyrana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582664/
https://www.ncbi.nlm.nih.gov/pubmed/31249546
http://dx.doi.org/10.3389/fpsyg.2019.01396
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author Fenner, Amberlynn S.
Webster, Kimberly T.
Ficek, Bronte N.
Frangakis, Constantine E.
Tsapkini, Kyrana
author_facet Fenner, Amberlynn S.
Webster, Kimberly T.
Ficek, Bronte N.
Frangakis, Constantine E.
Tsapkini, Kyrana
author_sort Fenner, Amberlynn S.
collection PubMed
description Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in detail, but it is not known whether it is effective for verb treatment in PPA. We addressed the question of whether performance in naming and spelling of verbs can be augmented with anodal tDCS over the left inferior frontal gyrus (IFG). We compared tDCS coupled with oral and written verb naming/spelling treatment with oral and written verb naming/spelling treatment alone. In a double-blind, sham-controlled, crossover design, 11 participants with logopenic or non-fluent variant PPA received approximately 15 consecutive sessions of anodal tDCS and sham over the left IFG coupled with oral and written verb-naming + spelling treatment. Written verb-naming performance improved significantly more for trained verbs in the tDCS than the sham condition. Importantly, tDCS effects generalized to untrained items for written verb naming and were significant even at 2 months post-treatment. We conclude that tDCS over the left IFG can improve written verb naming and spelling in PPA.
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spelling pubmed-65826642019-06-27 Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia Fenner, Amberlynn S. Webster, Kimberly T. Ficek, Bronte N. Frangakis, Constantine E. Tsapkini, Kyrana Front Psychol Psychology Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in detail, but it is not known whether it is effective for verb treatment in PPA. We addressed the question of whether performance in naming and spelling of verbs can be augmented with anodal tDCS over the left inferior frontal gyrus (IFG). We compared tDCS coupled with oral and written verb naming/spelling treatment with oral and written verb naming/spelling treatment alone. In a double-blind, sham-controlled, crossover design, 11 participants with logopenic or non-fluent variant PPA received approximately 15 consecutive sessions of anodal tDCS and sham over the left IFG coupled with oral and written verb-naming + spelling treatment. Written verb-naming performance improved significantly more for trained verbs in the tDCS than the sham condition. Importantly, tDCS effects generalized to untrained items for written verb naming and were significant even at 2 months post-treatment. We conclude that tDCS over the left IFG can improve written verb naming and spelling in PPA. Frontiers Media S.A. 2019-06-12 /pmc/articles/PMC6582664/ /pubmed/31249546 http://dx.doi.org/10.3389/fpsyg.2019.01396 Text en Copyright © 2019 Fenner, Webster, Ficek, Frangakis and Tsapkini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Fenner, Amberlynn S.
Webster, Kimberly T.
Ficek, Bronte N.
Frangakis, Constantine E.
Tsapkini, Kyrana
Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title_full Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title_fullStr Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title_full_unstemmed Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title_short Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
title_sort written verb naming improves after tdcs over the left ifg in primary progressive aphasia
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582664/
https://www.ncbi.nlm.nih.gov/pubmed/31249546
http://dx.doi.org/10.3389/fpsyg.2019.01396
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