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Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia
Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582664/ https://www.ncbi.nlm.nih.gov/pubmed/31249546 http://dx.doi.org/10.3389/fpsyg.2019.01396 |
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author | Fenner, Amberlynn S. Webster, Kimberly T. Ficek, Bronte N. Frangakis, Constantine E. Tsapkini, Kyrana |
author_facet | Fenner, Amberlynn S. Webster, Kimberly T. Ficek, Bronte N. Frangakis, Constantine E. Tsapkini, Kyrana |
author_sort | Fenner, Amberlynn S. |
collection | PubMed |
description | Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in detail, but it is not known whether it is effective for verb treatment in PPA. We addressed the question of whether performance in naming and spelling of verbs can be augmented with anodal tDCS over the left inferior frontal gyrus (IFG). We compared tDCS coupled with oral and written verb naming/spelling treatment with oral and written verb naming/spelling treatment alone. In a double-blind, sham-controlled, crossover design, 11 participants with logopenic or non-fluent variant PPA received approximately 15 consecutive sessions of anodal tDCS and sham over the left IFG coupled with oral and written verb-naming + spelling treatment. Written verb-naming performance improved significantly more for trained verbs in the tDCS than the sham condition. Importantly, tDCS effects generalized to untrained items for written verb naming and were significant even at 2 months post-treatment. We conclude that tDCS over the left IFG can improve written verb naming and spelling in PPA. |
format | Online Article Text |
id | pubmed-6582664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65826642019-06-27 Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia Fenner, Amberlynn S. Webster, Kimberly T. Ficek, Bronte N. Frangakis, Constantine E. Tsapkini, Kyrana Front Psychol Psychology Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, is an effective adjunct to naming treatments in post-stroke aphasia and primary progressive aphasia (PPA). Enhanced performance in oral and written naming and spelling of nouns with tDCS has been quantified in detail, but it is not known whether it is effective for verb treatment in PPA. We addressed the question of whether performance in naming and spelling of verbs can be augmented with anodal tDCS over the left inferior frontal gyrus (IFG). We compared tDCS coupled with oral and written verb naming/spelling treatment with oral and written verb naming/spelling treatment alone. In a double-blind, sham-controlled, crossover design, 11 participants with logopenic or non-fluent variant PPA received approximately 15 consecutive sessions of anodal tDCS and sham over the left IFG coupled with oral and written verb-naming + spelling treatment. Written verb-naming performance improved significantly more for trained verbs in the tDCS than the sham condition. Importantly, tDCS effects generalized to untrained items for written verb naming and were significant even at 2 months post-treatment. We conclude that tDCS over the left IFG can improve written verb naming and spelling in PPA. Frontiers Media S.A. 2019-06-12 /pmc/articles/PMC6582664/ /pubmed/31249546 http://dx.doi.org/10.3389/fpsyg.2019.01396 Text en Copyright © 2019 Fenner, Webster, Ficek, Frangakis and Tsapkini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Fenner, Amberlynn S. Webster, Kimberly T. Ficek, Bronte N. Frangakis, Constantine E. Tsapkini, Kyrana Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title | Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title_full | Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title_fullStr | Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title_full_unstemmed | Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title_short | Written Verb Naming Improves After tDCS Over the Left IFG in Primary Progressive Aphasia |
title_sort | written verb naming improves after tdcs over the left ifg in primary progressive aphasia |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582664/ https://www.ncbi.nlm.nih.gov/pubmed/31249546 http://dx.doi.org/10.3389/fpsyg.2019.01396 |
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