Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL. The LSD1 inhibitor phenelzine targeted both the flavin adeni...

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Detalles Bibliográficos
Autores principales: Tan, Abel H. Y., Tu, WenJuan, McCuaig, Robert, Hardy, Kristine, Donovan, Thomasina, Tsimbalyuk, Sofiya, Forwood, Jade K., Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582666/
https://www.ncbi.nlm.nih.gov/pubmed/31249575
http://dx.doi.org/10.3389/fimmu.2019.01351

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