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CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many stud...

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Autores principales: Righetti, Alessandra, Giulietti, Matteo, Šabanović, Berina, Occhipinti, Giulia, Principato, Giovanni, Piva, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582792/
https://www.ncbi.nlm.nih.gov/pubmed/31275385
http://dx.doi.org/10.1155/2019/9681698
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author Righetti, Alessandra
Giulietti, Matteo
Šabanović, Berina
Occhipinti, Giulia
Principato, Giovanni
Piva, Francesco
author_facet Righetti, Alessandra
Giulietti, Matteo
Šabanović, Berina
Occhipinti, Giulia
Principato, Giovanni
Piva, Francesco
author_sort Righetti, Alessandra
collection PubMed
description CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms.
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spelling pubmed-65827922019-07-03 CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer? Righetti, Alessandra Giulietti, Matteo Šabanović, Berina Occhipinti, Giulia Principato, Giovanni Piva, Francesco J Oncol Review Article CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms. Hindawi 2019-06-02 /pmc/articles/PMC6582792/ /pubmed/31275385 http://dx.doi.org/10.1155/2019/9681698 Text en Copyright © 2019 Alessandra Righetti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Righetti, Alessandra
Giulietti, Matteo
Šabanović, Berina
Occhipinti, Giulia
Principato, Giovanni
Piva, Francesco
CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title_full CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title_fullStr CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title_full_unstemmed CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title_short CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
title_sort cxcl12 and its isoforms: different roles in pancreatic cancer?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582792/
https://www.ncbi.nlm.nih.gov/pubmed/31275385
http://dx.doi.org/10.1155/2019/9681698
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