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Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension

AIMS: We report the cerebrospinal fluid opening pressure (CSF-OP) measurements obtained before and after venous sinus stenting (VSS) in 50 patients with idiopathic intracranial hypertension. METHODS: The CSF-OP was measured with a spinal tap 3 months before and 3 months after treatment. All data wer...

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Autores principales: Patsalides, Athos, Oliveira, Cristiano, Wilcox, Jessica, Brown, Kenroy, Grover, Kartikey, Gobin, Yves Pierre, Dinkin, Marc J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582809/
https://www.ncbi.nlm.nih.gov/pubmed/29871989
http://dx.doi.org/10.1136/neurintsurg-2018-014032
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author Patsalides, Athos
Oliveira, Cristiano
Wilcox, Jessica
Brown, Kenroy
Grover, Kartikey
Gobin, Yves Pierre
Dinkin, Marc J
author_facet Patsalides, Athos
Oliveira, Cristiano
Wilcox, Jessica
Brown, Kenroy
Grover, Kartikey
Gobin, Yves Pierre
Dinkin, Marc J
author_sort Patsalides, Athos
collection PubMed
description AIMS: We report the cerebrospinal fluid opening pressure (CSF-OP) measurements obtained before and after venous sinus stenting (VSS) in 50 patients with idiopathic intracranial hypertension. METHODS: The CSF-OP was measured with a spinal tap 3 months before and 3 months after treatment. All data were prospectively collected and included patient demographics, weight (kg), body mass index (BMI), acetazolamide daily dosage (mg), procedural details, complications, venous sinus pressures (mm Hg), trans-stenotic pressure gradient (mm Hg), transverse sinus symmetry, and type of venous sinus stenosis. RESULTS: The average pretreatment CSF-OP was 37 cm H(2)O (range 25–77) and the average post-treatment CSF-OP was 20.2 cm H(2)O (range 10–36), with an average reduction of 16.8 cm H(2)O (P<0.01). The post-treatment CSF-OP was less than 25 cm H(2)O in 40/50 patients. The average acetazolamide daily dose decreased from 950 mg to 300 mg at the time of 3-month follow-up (P<0.01). No patient required an increase in acetazolamide dose 3 months after VSS. The average weight before treatment was 95.4 kg with an average BMI of 35.41. There was an average increase in body weight of 1.1 kg at the 3-month follow-up with an average increase in BMI of 0.35 (P=0.03). CONCLUSIONS: We provide evidence that there is a significant decrease in CSF-OP in patients with idiopathic intracranial hypertension 3 months after VSS, independent of acetazolamide usage or weight loss.
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spelling pubmed-65828092019-07-05 Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension Patsalides, Athos Oliveira, Cristiano Wilcox, Jessica Brown, Kenroy Grover, Kartikey Gobin, Yves Pierre Dinkin, Marc J J Neurointerv Surg Clinical Neurology AIMS: We report the cerebrospinal fluid opening pressure (CSF-OP) measurements obtained before and after venous sinus stenting (VSS) in 50 patients with idiopathic intracranial hypertension. METHODS: The CSF-OP was measured with a spinal tap 3 months before and 3 months after treatment. All data were prospectively collected and included patient demographics, weight (kg), body mass index (BMI), acetazolamide daily dosage (mg), procedural details, complications, venous sinus pressures (mm Hg), trans-stenotic pressure gradient (mm Hg), transverse sinus symmetry, and type of venous sinus stenosis. RESULTS: The average pretreatment CSF-OP was 37 cm H(2)O (range 25–77) and the average post-treatment CSF-OP was 20.2 cm H(2)O (range 10–36), with an average reduction of 16.8 cm H(2)O (P<0.01). The post-treatment CSF-OP was less than 25 cm H(2)O in 40/50 patients. The average acetazolamide daily dose decreased from 950 mg to 300 mg at the time of 3-month follow-up (P<0.01). No patient required an increase in acetazolamide dose 3 months after VSS. The average weight before treatment was 95.4 kg with an average BMI of 35.41. There was an average increase in body weight of 1.1 kg at the 3-month follow-up with an average increase in BMI of 0.35 (P=0.03). CONCLUSIONS: We provide evidence that there is a significant decrease in CSF-OP in patients with idiopathic intracranial hypertension 3 months after VSS, independent of acetazolamide usage or weight loss. BMJ Publishing Group 2019-02 2018-06-05 /pmc/articles/PMC6582809/ /pubmed/29871989 http://dx.doi.org/10.1136/neurintsurg-2018-014032 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Clinical Neurology
Patsalides, Athos
Oliveira, Cristiano
Wilcox, Jessica
Brown, Kenroy
Grover, Kartikey
Gobin, Yves Pierre
Dinkin, Marc J
Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title_full Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title_fullStr Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title_full_unstemmed Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title_short Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
title_sort venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension
topic Clinical Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582809/
https://www.ncbi.nlm.nih.gov/pubmed/29871989
http://dx.doi.org/10.1136/neurintsurg-2018-014032
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