Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

Channelrhodopsin2 (ChR2) optogenetic excitation is widely used to study neurons, astrocytes, and circuits. Using complementary approaches in situ and in vivo, we found that ChR2 stimulation leads to significant transient elevation of extracellular potassium ions by ~5 mM. Such elevations were detect...

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Detalles Bibliográficos
Autores principales: Octeau, J. Christopher, Gangwani, Mohitkumar R., Allam, Sushmita L., Tran, Duy, Huang, Shuhan, Hoang-Trong, Tuan M., Golshani, Peyman, Rumbell, Timothy H., Kozloski, James R., Khakh, Baljit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582980/
https://www.ncbi.nlm.nih.gov/pubmed/31116972
http://dx.doi.org/10.1016/j.celrep.2019.04.078

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