Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales

The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emerg...

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Autores principales: Kamaludeen, Juriah, Graham-Brown, John, Stephens, Nathalie, Miller, Josephine, Howell, Alison, Beesley, Nicola J, Hodgkinson, Jane, Learmount, Jane, Williams, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583106/
https://www.ncbi.nlm.nih.gov/pubmed/30824600
http://dx.doi.org/10.1136/vr.105209
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author Kamaludeen, Juriah
Graham-Brown, John
Stephens, Nathalie
Miller, Josephine
Howell, Alison
Beesley, Nicola J
Hodgkinson, Jane
Learmount, Jane
Williams, Diana
author_facet Kamaludeen, Juriah
Graham-Brown, John
Stephens, Nathalie
Miller, Josephine
Howell, Alison
Beesley, Nicola J
Hodgkinson, Jane
Learmount, Jane
Williams, Diana
author_sort Kamaludeen, Juriah
collection PubMed
description The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms.
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spelling pubmed-65831062019-07-05 Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales Kamaludeen, Juriah Graham-Brown, John Stephens, Nathalie Miller, Josephine Howell, Alison Beesley, Nicola J Hodgkinson, Jane Learmount, Jane Williams, Diana Vet Rec Paper The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms. BMJ Publishing Group 2019-04-20 2019-03-01 /pmc/articles/PMC6583106/ /pubmed/30824600 http://dx.doi.org/10.1136/vr.105209 Text en © British Veterinary Association 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Paper
Kamaludeen, Juriah
Graham-Brown, John
Stephens, Nathalie
Miller, Josephine
Howell, Alison
Beesley, Nicola J
Hodgkinson, Jane
Learmount, Jane
Williams, Diana
Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title_full Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title_fullStr Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title_full_unstemmed Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title_short Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
title_sort lack of efficacy of triclabendazole against fasciola hepatica is present on sheep farms in three regions of england, and wales
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583106/
https://www.ncbi.nlm.nih.gov/pubmed/30824600
http://dx.doi.org/10.1136/vr.105209
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