Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats

PURPOSE: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. METHODS: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia...

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Detalles Bibliográficos
Autores principales: Eken, Hüseyin, Cimen, Orhan, Cimen, Ferda Keskin, Kurnaz, Eray, Yildirim, Murat, Tasova, Volkan, Kurt, Nezahat, Pehlivanoglu, Kamil, Onk, Didem, Bilgin, Asli Ozbek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019
Materias:
ORIGINAL ARTICLE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583928/
https://www.ncbi.nlm.nih.gov/pubmed/31066786
http://dx.doi.org/10.1590/s0102-865020190040000004
Descripción
Sumario:PURPOSE: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. METHODS: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. RESULTS: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. CONCLUSION: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.

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