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Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms

Protein kinase B (AKT) is a serine/threonine kinase that functions as an important downstream effector of phosphoinositide 3-kinase. We have recently shown that MK-2206 and triciribine, two highly selective AKT inhibitors increase the level of low density lipoprotein receptor (LDLR) mRNA which leads...

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Detalles Bibliográficos
Autores principales:	Bjune, Katrine, Wierød, Lene, Naderi, Soheil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583949/ https://www.ncbi.nlm.nih.gov/pubmed/31216345 http://dx.doi.org/10.1371/journal.pone.0218537

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