Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways

The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and progn...

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Detalles Bibliográficos
Autores principales: Der, Evan, Suryawanshi, Hemant, Morozov, Pavel, Kustagi, Manjunath, Goilav, Beatrice, Ranabathou, Saritha, Izmirly, Peter, Clancy, Robert, Belmont, H. Michael, Koenigsberg, Mordecai, Mokrzycki, Michele, Rominieki, Helen, Graham, Jay A., Rocca, Juan P., Bornkamp, Nicole, Jordan, Nicole, Schulte, Emma, Wu, Ming, Pullman, James, Slowikowski, Kamil, Raychaudhuri, Soumya, Guthridge, Joel, James, Judith, Buyon, Jill, Tuschl, Thomas, Putterman, Chaim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584054/
https://www.ncbi.nlm.nih.gov/pubmed/31110316
http://dx.doi.org/10.1038/s41590-019-0386-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584054/
https://www.ncbi.nlm.nih.gov/pubmed/31110316
http://dx.doi.org/10.1038/s41590-019-0386-1

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